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Hydrochlorothiazide studies in which hydrochlorothiazide was orally administered to pregnant mice and rats during their respective periods of major organogenesis at doses up to 3000 and 1000 mg kg day, respectively, provided no evidence of harm to the fetus.
In patients who have had their heart valve replaced with a metal mechanical heart valve, they may be taking warfarin coumadin which can cause risk to the fetus and alternative means of blood thinning may be required.
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